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Shoemaker Protocol


Chronic Inflammatory Response Syndrome (CIRS)

is a disorder of the innate immune system. It has a number of causes. The most common cause of CIRS is mold in water-damaged buildings. Some of the other causes are Ciguatera, Pfiesteria, 

cyanobacteria, algae blooms (red tide), and brown recluse spider bites.

Water-damaged buildings do not affect everyone equally: some people may be very ill while others may feel nothing at all in the

very same building. About a quarter of the population has 

a direct, genetic vulnerability to mold in water-damaged buildings. These people cannot create the antibodies needed to remove the biotoxins. Without these antibodies, they become sick and stay sick. Even if they leave the water-damaged building, the patient will not get better without medical intervention. They may become increasingly more sensitive to ever-smaller exposures in a phenomenon we call "sicker, quicker."


According to NIOSH, half the buildings in the U.S. are water-damaged. Exposure most commonly occurs in the home, workplace and/or school. Any moisture that is not remediated completely within 48 hours can potentially cause illness in the vulnerable portion of the population. Common sources include leaks in the basement or a roof, plumbing leaks, and issues from air-conditioning and ventilation systems.


Although patients may have acquired CIRS from different sources, symptoms are generally similar. Some of the common symptoms

may include:

  • fatigue

  • poor sleep

  • headaches

  • abdominal pain

  • diarrhea 

  • difficulty breathing and cough

  • muscle pain and cramping 

  • numbness and tingling

  • frequent urination

  • heart palpitations 

  • blurry vision 

  • anxiety 

  • depression 

  • word-finding difficulties 

  • "brain fog" and cognitive issues


The Shoemaker Protocol is a step-by-step approach to complex health issues caused by biotoxin illness. To date, this is the only therapy to have each step supported by rigorous, evidence-based, peer-reviewed research. CIRS can be verified with symptom review, visual contrast sensitivity test (VCS), bloodwork, NeuroQuant MRI changes, and genomics (GENIE). GENIE can demonstrate changes in genetic expression with CIRS, confirming a diagnosis and giving insight into individualized treatment. ​

Dr. Shoemaker's website:

Dr. Shoemaker's book The Art and Science of CIRS Medicine provides an in--depth look at the latest science on CIRS:

Dr. Shoemaker's Youtube channel:

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